At high doses, metoprolol also blocks beta-2 receptors within the lungs and airways (which may affect breathing). Metoprolol works by blocking the effects of epinephrine on beta-1 receptors within the heart tissue, causing the heart to pump more slowly and with less force.Metoprolol is a medication that may be used to treat or prevent various heart conditions.Medically reviewed by Carmen Pope, BPharm.